UAlbany Researchers Advance New Technique for Direct RNA Sequencing
University at Albany's Department of Chemistry features DirectSeq Biosciences
founder and associate professor Shenglong Zhang and his team's latest breakthrough —
3D NGMS-Seq, a three-dimensional next-generation mass spectrometry sequencing platform
published in Nucleic Acids Research. The article highlights how the technique
directly sequences RNA, including all chemical modifications, without prior sequence
input — uncovering hidden impurities and isomers in therapeutic RNA samples that
conventional methods miss entirely.